Recombinant Human Neurotrophin-3 (NT-3)


Human Neurotrophin-3 (NT-3) is a member of the neurotrophin family.

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SKU OPTIONS PriceQuantity
HNT3-100 100 ug,1 mg/ml $317.00
HNT3 -200 1 mg,1 mg/ml $2,697.00
HNT3 -OEM Any size Please inquire


Neurotrophins are growth factors that modulate growth, differentiation, and survival of neurons. Structure related proteins include neuron growth factor (NGF), brain derived neurogenic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5. They are highly homologous and share a similar structure of a tertiary folded, cysteine rich “knot”. Neurotrophins are critical to the development of the central and peripheral nervous system and they play important roles in injury induced neuron regeneration.

NT-3 is encoded by the NTF3 gene, and is the only neurotrophin that affects the development of the enteric nervous system. NT-3 primarily activates the TrkC tyrosine kinase receptor. In addition, NT-3 can activate Trk and TrkB kinase receptors in certain cell systems. NT-3 can also bind with low affinity to the low affinity NGF receptor. Dysregulation of NT-3 is known to be related with neuroblastoma, Alzhiemer’s, Huntington’s, and Parkinson’s Disease. Due to the broad cell poplulations affected by NT-3, the control of NT-3-TrkC pathway has become a target for therapeutical approach for neurogenic diseases.

Full Name
Human Neurotrophins-3

E. coli


Accession #

Molecule Weight
NT-3 recombinant protein is a noncovalent linked homodimer. The 120 amino acid recombinant protein has a predicted molecular mass of approximately 13.6 kD as monomer, 26.5 kD as dimer

> 95 % as determined by SDS-PAGE

< 1.0 EU per μg of the protein as determined by the LAL method

The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml, corresponding to a specific activity of 2-5 x 104 units/mg.

-80 Avoid repeated freeze-thaw cycles.

Storage Buffer

Additional information


100 ug,1 mg/ml, 1 mg,1 mg/ml, Any size

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